Solution Science for Research and Industry

Posts tagged “microscopy

March 2019 newsletter now online

March 2019 NewsletterThe Elliot Scientific March newsletter is now available. In this special life science issue we reveal how WITec’s new ParticleScout can help quickly identify and quantify, pollutants, unveil three new videos of products for microscopy and optogenetics from Prizmatix, announce that Siskiyou’s range of motorised manipulators are now available in the UK and Ireland, and show how Digital Holographic Microscopy from Lyncee Tec can help the research scientist, plus Magnetism 2019 in Leeds next month.

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Motorised Siskiyou micromanipulators for bioscience (and microelectronics)

For interaction with a microscope sample, the micromanipulator has been a staple of the biologists toolkit from the beginning of the 20th century.

Used for holding, injecting or cutting, the precision of the micromanipulator’s motion has always been paramount. So many leading researchers, including Dr Robert Chambers and Sir Andrew Huxley, worked on improving the mechanics of these systems over the years.

These early devices relied on adjustment of the individual axes by hand, but by the 1950’s De Fonbrune had developed a pneumatic micromanipulator that allowed all three axes to be operated via a joystick-like controller.

Depending on the application, researchers might need different movement ranges and resolutions, speeds and accuracy; so ranges of micromanipulators are available of different constructions to suit.

Siskiyou Corporation offer mechanical, hydraulic, and electronically-controlled motor adjusted systems.

The latter micromanipulators are fully CE-certified and are now on sale to UK and Irish researchers. Models available include:

MX1641 Series – ideal for introductory level research and training
This crossed roller micromanipulator uses spring-loaded lead screws on three axes to ensure drift-free operation, and a motorised probe axis delivering up to 0.1 µm movement resolution.

MX7600 Series – ideal for patch recording experiments
A fully motorised crossed roller bearing micromanipulator offering exceptionally smooth linear travel via its precision preloaded lead screws to ensure drift-free operation and up to 0.1 µm movement resolution.

MX7800 Series – ideal for multiple patch-recording experiments
This variant of MX7600 series uses a new folded Y-axis stage that narrows the footprint of the manipulator by half. This design enables the mounting of as many as six micromanipulators in a semi­circle from side to side around the front of a microscope.

For more information, please visit our Siskiyou Life Science Products, or contact us.

PS. Micromanipulators can also be useful for holding tools and probes while examining microelectronics under a microscope!

 


Using the most powerful single-chip LEDs available, Prizmatix LEDs are ideal for microscopy and optogenetics research

Prizmatix LEDs for Optogenetics and Fluorescence
  • High-power collimated and fibre-coupled LEDs
  • Wavelengths available from UV to Red
  • White Light and Multiple LED Sources

Prizmatix specialises in LED illumination systems for industrial applications, and science, especially in microscopy and optogenetics research.

The Prizmatix High Power and Ultra-High-Power (UHP) models are built using the most powerful single-chip LEDs available. These versatile illumination solutions offer:

Modularity
The modular systems deliver flexibility with a collimated beam. Fitted with a standard SM1 thread at the port, they can be fitted with a variety of accessories such as a fibre coupler adaptor, beam combiner, filter wheel, and more. The accessories are easy to fit and swap, so different set-ups only take minutes.

High efficiency
The fibre-coupled LED models have a highly efficient coupling that optimises the output such that these systems deliver roughly 1.5x more light when compared to Prizmatix LEDs used with a fibre adaptor. The LED controller is in-built to maximise its compactness.

Wide range of powers
High Power LED models are equipped with a 1 mm² single chip LED and can deliver up to 300 mW of optical power, while the UHP models have a 12 mm² single chip LED punching out up to 5 W of optical power. (As measured after the collimating optics)

Broad range of wavelengths
Choose from dozens of standard LEDs that operate at monochromatic wavelengths between 340 and 940 nm, and ‘white’ light models with a choice of spectral outputs. Deep UV and IR LEDs are also available on request.

Controls
Each of the extremely low-noise LED controllers has TTL and analogue input. In combination with a USB-control box, the LEDs can be controlled from a PC using µManager, LabView, Matlab or directly using HyperTerminal commands. An optional photodiode feedback loop enables the LEDs to be power stabilised.

Accessories
In addition to fibre coupling adaptors, collimators and filter wheels, custom-made fibres and fibre bundles with high numerical apertures of up to 0.63 are available. Optogenetics researchers can also order cannulae, rotary joints, and programmable signal generators for use in their experiments.

For more information, please visit our Prizmatix webpages or contact us.

 


February 2019 newsletter now online

February 2019 NewsletterThe Elliot Scientific February newsletter is now available. In this issue we go in deep with Lyncee Tec’s R-Series of Digital Holographic Microscopes, welcome the return of OptiBlocks from Prizmatix to our webpages, announce a training capability for spectroscopists interested in Raman Imaging from WITec, and recommend fiber optic components manufactured by market leader OZ Optics.

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January 2019 newsletter now online

January 2019 NewsletterThe Elliot Scientific January newsletter is now available. In this issue we say hello to Digital Holographic Microscopy specialists Lyncée Tec as we expand our life science range of products that currently come from Accurion, CRAIC Technologies, Elliot Scientific, HOLOEYE, Kinetic Systems, Prizmatix, Siskiyou, Tecella, and WITec. We also look at Lake Shore’s new M91 FastHall controller and remind you of next month’s Photonics West.

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Elliot Scientific’s 2018 newsletters published in one volume

Elliot Scientific’s renowned monthly newsletters have been compiled into a single edition for the year 2018.

The 32-page volume can be:

Read online via Issuu

Downloaded from our website

or viewed by clicking here


December 2018 newsletter now online

December 2018 NewsletterThe Elliot Scientific December newsletter is now available. In this issue we start offering WITec confocal Raman imaging solutions within the UK and Ireland, Mad City Labs say Nano-ZL is ideal for high-speed multiwell plate imaging, Rugged Monitoring introduce multi-channel capability with new T301 module, and Seebeck coefficient measurement is explained in a video from DEMCON|kryoz, plus our winter holiday schedule.

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Elliot Scientific now representing Raman Imaging specialists WITec in the UK and Eire

Unique correlative analysis in one instrument: Raman/AFM, Raman/SNOM

Elliot Scientific has signed an exclusive distribution agreement with WITec GmbH, of Ulm in Germany, to distribute their range of award-winning Raman imaging instruments.

WITec is a market leading manufacturer of high-quality micro- and nano-analytical imaging equipment featuring confocal Raman microscopy, Atomic Force Microscopy (AFM) and Scanning Near-field Optical Microscopy (SNOM) techniques for the geoscience researcher, forensic scientist, pharmaceutical lab technician, semiconductor manufacturer, and food and drinks technologist.

The WITec product line of high-resolution SNOM, AFM and confocal Raman imaging solutions will be the responsibility of our Managing Director, Dr. Adrian Knowles.

Adrian is a qualified chemist and is well known within the spectroscopy community, especially within the field of Raman spectroscopy. His knowledge encompasses a wide range of technologies that include CCD cameras, fibre-optics, microscopy systems, Raman spectrometers and fluorimeters. His broad market visibility has been fundamental in the success and growth of several photonics and spectroscopy companies during his 20 year career.

Our team of scientists and engineers has nearly 30 years of experience in sales of light-based technologies to academia and industry. With expertise in key WITec application areas of forensics, geoscience, the life sciences, materials science, photonics and semiconductors, Elliot Scientific is the ideal partner for supporting WITec instruments within the UK and Ireland.

More information can be found on our website at www.elliotscientific.com/Raman-Imaging


New High Brightness White Light Fibre Coupled Light Source from Prizmatix

The HB-FC-White high-brightness fibre-coupled light sources from Prizmatix are designed especially for OEM illumination applications in life science instrumentation, machine vision.

The HB-FC-White is a self-contained light source that includes all the necessary driver electronics and a thermal management system – no special controller box is required to operate the unit if used at the preset power.

  • Single chip long-life LED
  • High brightness cool-white light
  • High power from a small core fibre
  • Isolated TTL and analogue input
  • Optional fast TTL switching (200 ns)
  • Low optical noise
  • Optional remote control
  • Optional USB or RS-232 control
  • For OEMS:
    • Simple integration
    • I²C remote control protocol

Typical optical power from distal end of 1 m fibre:

Fibre Type Fibre Core Fibre NA Output Power
Polymer 1000 µm 0.63 460 mW
Polymer 500 µm 0.63 245 mW
Glass 250 µm 0.66 110 mW
Silica 50 µm 0.2 0.5 mW

For more information, please contact us.

 


November 2018 newsletter now online

November 2018 NewsletterThe Elliot Scientific November newsletter is now available. In this issue a new digital micromirror device (DMD) is announced by Prizmatix for targeting light, and we also show off their UHP-M light source, both for microscopy; Lake Shore Cryotronics distributed cryogenic temperature sensing systems get a mention, along with IPG‘s ultrafast lasers; and we finish off with how capacitance measurement equipment from Andeen-Hagerling can help in a huge variety of research and industrial applications.

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Prizmatix impresses at Neuroscience 2018

Prizmatix has been wowing the crowds at Neuroscience 2018 in San Diego this week with their self-contained UHP-M, an ultra-high power UV & Visible light source for many microscopy applications.

Incorporating two independently controllable Prizmatix large-chip LEDs, the UHP-M delivers broadband white light from a single 55 W LED, and high power UV from a single 10 W LED operating at 365, 385 or 405 nm depending on model ordered. The UHP-M offers:

  • Optically isolated TTL & analogue inputs
  • Fast TTL switching
  • Low optical noise
  • Long life (no lamp replacement)
  • Fanless operation
  • Remote control*
  • USB interface*

* The UHP-M requires no external control if operating at full power. However, if power levels need to be adjusted, the optional remote control or USB interface will be required.

Prizmatix also announced the introduction of a digital micromirror device (DMD) module for delivering light to cellular and subcellular targets. Applications include: optogenetics, uncaging, photoactivation and fluorescence recovery after photobleaching (FRAP).

The one megapixel DMD utilises a grid of 914 by 1140 independently controllable micromirrors to divert light to specific areas under study at over 1000 times per second.

This exciting new product offers almost spatial light modulator (SLM) performance without the need to use lasers, and we’ll know more about it soon.

There’s still time to visit Prizmatix in booth 3333 as Neuroscience 2018 continues until November 7th.

 


New Ultra High Power LEDs for Microscopy, Spectroscopy and Optogenetics from Prizmatix

The range of LED light delivery products for microscopy, spectroscopy, optogenetics, and other scientific research and industrial applications from Prizmatix, has been further expanded with the introduction of even higher power white light sources.

As a scientist-led company, Prizmatix understands the requirements of researchers when designing LED illumination systems. Available through Elliot Scientific in the UK and Ireland, this broad range of powerful LEDs operate across the spectrum for applications that include:

  • For microscopy and imaging – The UHP-T LED, one of the most powerful available today
  • Optogenetics – Single and dual wavelength systems for in-vivo and in-vitro research
  • Multi-wavelength LED systems offering modularity and versatility for customised setups
  • Fibre-coupled units, with up to 11 different LEDs, delivering light through a range of fibre options

STSI-All-250-1For in-vivo and in-vitro optogenetics, Prizmatix offer a full range of modules that start from single wavelength plug-and-go kits, to multi-wavelength systems for activation and silencing in the same fibre. From light sources to cannulae, and everything in between, Prizmatix provides all the components necessary for experimenters in neuroscience, neurobiology, electrophysiology, biochemistry and biophysics. Typical systems have been constructed by researchers for:

  • Detection & excitation
  • Intensity monitoring
  • In-line filtering, attenuation or polarisation
  • Reflectance or fluorescence detection for in situ, in vivo, or in vitro applications

Prizmatix have extensively developed various photonics products for use in neuro and bioscience research such as optogenetics, as well as traditional chemistry, biology and physics. For example, fluorescence and Raman spectroscopy, microscopy, and absorption measurement are typical applications.