For interaction with a microscope sample, the micromanipulator has been a staple of the biologists toolkit from the beginning of the 20th century.
Used for holding, injecting or cutting, the precision of the micromanipulator’s motion has always been paramount. So many leading researchers, including Dr Robert Chambers and Sir Andrew Huxley, worked on improving the mechanics of these systems over the years.
These early devices relied on adjustment of the individual axes by hand, but by the 1950’s De Fonbrune had developed a pneumatic micromanipulator that allowed all three axes to be operated via a joystick-like controller.
Depending on the application, researchers might need different movement ranges and resolutions, speeds and accuracy; so ranges of micromanipulators are available of different constructions to suit.
Siskiyou Corporation offer mechanical, hydraulic, and electronically-controlled motor adjusted systems.
The latter micromanipulators are fully CE-certified and are now on sale to UK and Irish researchers. Models available include:
MX1641 Series – ideal for introductory level research and training
This crossed roller micromanipulator uses spring-loaded lead screws on three axes to ensure drift-free operation, and a motorised probe axis delivering up to 0.1 µm movement resolution.
MX7600 Series – ideal for patch recording experiments
A fully motorised crossed roller bearing micromanipulator offering exceptionally smooth linear travel via its precision preloaded lead screws to ensure drift-free operation and up to 0.1 µm movement resolution.
MX7800 Series – ideal for multiple patch-recording experiments
This variant of MX7600 series uses a new folded Y-axis stage that narrows the footprint of the manipulator by half. This design enables the mounting of as many as six micromanipulators in a semicircle from side to side around the front of a microscope.
PS. Micromanipulators can also be useful for holding tools and probes while examining microelectronics under a microscope!
Elliot Scientific has signed an exclusive distribution agreement with Lyncée Tec SA, of Lausanne in Switzerland, to distribute and support their range of holographic microscopes based on the revolutionary patented Digital Holographic Microscope (DHM®) technology.
DHM® are 3D optical profilometers characterised by an unrivalled high measurement rate and a very short exposure time. These unique features make possible applications not conceivable using white light interferometers and confocal microscopes: 3D topography measurements in presence of environmental vibration or of intrinsic sample vibration, sample characterization in cryogenic and high temperature environments, large area screening, and analysis of the deformation dynamics of samples due to external stimuli such as temperature and pressure changes, light irradiance, mechanical force, or electromagnetic fields.
In life sciences, DHM® enables label-free non-invasive millisecond to multi-days continuous measurement of cells. Quantitative phase measurements provide quantitative information about cell morphology and intracellular content, cell proliferation and viability, trans-membrane ionic currents and water transport among others.
“We are excited to work with Elliot Scientific, an innovative company with a highly qualified staff that will provide the highest levels of service and knowledge. DHM® are complementary to Elliot’s product line.” said Dr. Yves Emery, CEO of Lyncée Tec. “This agreement enables us to provide high quality products, services, as well as scientific and technological support.”
More information can be found on the Elliot Scientific website at www.elliotscientific.com/Lyncee-Tec-Digital-Holographic-Microscopes
About Lyncée Tec SA
Founded in 2003, Lyncée Tec SA is the leading company in the field of Digital Holography Microscopy (DHM®). The company offers directly and through distribution and OEM partners a broad range of products covering sample holders and conditioning accessories, stand alone and camera-like DHM®, and software modules for efficient analysis of measurement data. Systems have been designed specifically both for R&D and for quality inspection. They are used in the fields of micro production, industrial metrology, MEMS, semi-conductor, micro-optics, watch industry, and cell imaging. For more information, please visit www.lynceetec.com
Since 2007 Tecella has supplied electrophysiology measurement systems that allow pharmaceutical researchers to rapidly screen drugs and medical compounds thereby accelerating and improving drug discovery. Now Elliot Scientific enables scientists in the UK and Ireland to purchase their products.
Tecella offer a range of instruments for electrophysiology; from the single channel Pico to the 384-channel Apollo – designed for high throughput screening (HTS) systems.
In addition to electrophysiology, researchers working in electrochemistry, mems and other biotech fields can benefit from Tecella’s highly scalable amplifier architectures and fully customisable software and hardware solutions.
Elliot Scientific is now offering products from the Siskiyou range of micromanipulators, microscope sample positioners, and modular opto-mechanical building blocks to researchers in the British Isles.
Products include highly precise micromanipulators, stages, optical mounts, adjusting screws, clamps, rods, and much more.
Siskiyou products are Modular by Design™, which makes it easy to substitute interchangeable parts or to exchange and add modular units. This ability provides an unlimited array of functional tools that can be adapted to most any requirement.