Solution Science for Research and Industry

Lifescience

March 2020 newsletter now online

The Elliot Scientific March 2020 Newsletter has been sent out: view it here.

In this month’s issue…

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November 2019 newsletter now online

The Elliot Scientific November 2019 Newsletter is now online

In this month’s issue…

Rugged Monitoring announce an addition to their range of fibre optic temperature monitors and that they’ve been awarded ISO 9001:2015 certification.

Gamma Scientific release an OEM version of their flagship SpectralLED light source, the tunable LED-based RS-7.

We introduce 3 new filters from the NoIR Laser range of protective eyewear for users working with lasers and other intense light sources.

…and round off with a look at Professor Wolfgang Drexler working on Optical Coherence Tomography at the Centre for Medical Physics and Biomedical Engineering in Vienna.

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WITec are at MMC in Manchester from Monday

The Microscience Microscopy Congress (MMC) takes place from Monday, July 1st to Thursday the 4th at Manchester Central.

With 36 conference sessions, an exhibition with more than 100 companies, workshops, training opportunities and a busy social programme it’s the must-attend event for the UK’s microscopy community.

WITec, pioneers of commercial 3D Raman imaging and correlative microscopy are exhibiting on Stand 331 and Elliot Scientific will be supporting them.

The company continues to lead the industry with a unique product portfolio that offers speed, sensitivity and resolution without compromise. Raman, AFM, SNOM and SEM (RISE) microscopes, and combinations thereof, are offered for specific challenges in chemical and structural characterisation through a modular hardware architecture and flexible software combination.

 

 


June 2019 newsletter now online

June 2019 NewsletterThe Elliot Scientific June 2019 Newsletter: In this issue we welcome nPoint and their range of piezo-actuated nanopositioning flexure stages, and Microscope Heaters who do what it says on their tin – heat microscopes with fanless incubation systems. We also announce that our Optical Tweezer systems now come with Microsoft’s Windows 10, and that EXFO have launched the Optical Xplorer – the world’s first OFM. Plus Laser World of Photonics in Munich next week and a whole host of materials science and microscopy trade shows coming up next month.

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Microscope incubation systems, stage heaters and more from DPMH

Surrey-based Digital Pixels has been designing and supplying equipment for the research microscopy community throughout the world for nearly two decades. More recently, under the Microscope Heaters brand, they have developed, designed and manufactured a wide range of fanless enclosure systems for maintaining cell viability within microscope applications for leading universities and research institutes.

Incubation Systems for Leica, Nikon, Olympus and Zeiss et al

Vibration-free microscope heating systems deliver the ultimate in thermal homogeneity and stability. Ideal for the more demanding microscopy techniques such as Super Resolution, Optical Tweezers or electrophysiology: even users of x60 or x100 objectives can benefit as focus drift is reduced. These solid-state heaters can maintain 1 to 50 °C heat above ambient depending on configuration, thus allowing for a wider range of samples to be studied. Inherent reliability means less down time during time-lapse experiments.

Stage Top Heaters

These assemblies have independent temperature control over the insert, and the insert’s glass top. They are sealed to maintain CO2 or CO2-O2 gas control, and accept a 3 mm tube for gas delivery.

Open Heated Inserts

Patch clamp and perfusion studies, where access to the sample is essential, benefit from this type of system. It has an optional dual temperature control configuration for controlling the temperature of the heated insert, and the temperature of media entering the sample area.

Intravital Microscopy Imaging System

Specially designed for whole animal viability during extended imaging experiments, the system has two independent temperature control channels – one for the removable heated insert, the other for a heated blanket. Titanium windows complete the system.

Gas Control Solutions

A number of cell systems often require a closely controlled CO2 concentration to maintain cell viability over extended periods of time. Although achievable using a 5% CO2 cylinder, these expensive and bulky solutions are limited in their ability to deliver flexible and reliable gas concentrations. Microscope Heaters offer three, high-performance, microprocessor controlled solutions that only require a single 100% CO2 gas supply.

Visit our website for more information, or contact us for further details now.


nPoint Piezo Nanopositioners now available through Elliot Scientific

Elliot Scientific is pleased to announce that it has been selected by nPoint, Inc. to be the exclusive UK and Ireland distributor of their nanopositioning solutions.

nPoint specialises in piezo actuator driven flexure stages available in one, two or three axes of motion. In conjunction with their ultra-precision motion control scanners and controllers, users can achieve the highest levels of performance available in the marketplace. Typical application areas are:

Life Science / Microscopy – piezo stages provide accurate, fast, and repeatable motion that enable high-throughput data acquisition and processing for techniques such as super resolution microscopy, sample scanning, autofocus, and cell tracking.

Semiconductor / Data Storage – nanopositioners are used in production, development, and inspection of silicon wafers and hard disk recording heads.

Optics – high speed nanopositioners enable movement of an optic for a multitude of precision applications such as scanning, laser beam steering, phase shifting, dithering and focusing.
AFM / Materials Science – piezo stages have been traditionally used as closed-loop scanners for Atomic Force Microscopes, offering extremely low out-of-plane motion, no piezo drift, exceptional scanning linearity, and longer travel ranges.

Photonics Packaging / Communications – in fibre optics, nanopositioning stages have become critical for speedy and optimal alignment duties.

Elliot Scientific will be demonstrating nPoint technology at various UK trade events this year, and looks forward to enabling researchers and OEMs achieve significant benefits from incorporating nPoint systems within their applications.

Click here to see the range, or contact us for further information.

 

 


Raman Microscopy for Microparticle Analysis Webinar

Early next week, a webinar entitled Raman Microscopy for Microparticle Analysis: Find, Classify and Identify is being broadcast by WITec and Nature.

It takes place on Tuesday, June 4th at 16:00 BST, that is 08:00 PDT,  11:00 EDT, and 17:00 CEST.

Dr. David Steinmetz and Dr. Miriam Böhmler from WITec GmbH will give an introduction to Raman microscopy and automated particle analysis.

They will be followed by Dr. Natalia Ivleva, from TU Munich, who will present her work on microplastic pollution in environmental samples as an application example.

For more information and registration, please visit the webinar homepage.


16th Confocal Raman Imaging Symposium announced

Speakers from Germany, the USA and China will be at the 16th Confocal Raman Imaging Symposium being organised by our friends WITec in September.

Running from the 23rd to the 25th in Ulm, Germany, the symposium will cover aspects of modern Raman imaging and include a poster session detailing recent results in Raman imaging from various scientific fields.

An in-depth introduction to the operational principles and instrumental configurations relevant to confocal Raman microscopy will also be held at the equipment demonstrations.

During the three-day conference participants will be able to have in-depth discussions and networking opportunities with leading scientists and users of WITec microscope systems.

So, if you’re a scientist interested in chemically identifying and imaging samples at the highest spatial resolution, sign up here.

 

 


Iridian filters now available from Elliot Scientific

The Iridian range of filters for imaging, fluorescence, Raman and optical spectroscopy is now available in the UK and Ireland through Elliot Scientific.

Iridian-Banner-0

Scores of filters designed for bandpass – both short and long, edge pass, narrow notch and dichroic mirrors have been added to our website.

They are used in many spectroscopic investigations such as flow and emission cytometry, excitation and emission fluorescence, and more. Imaging filters for use in machine vision applications are available too.

We can also advise on custom filters for very specific scientific applications, and welcome OEM enquiries.

Please contact us for details, or visit our Iridian pages.


New patch clamp amplifiers from Tecella

Since 2007 Tecella has supplied electrophysiology measurement systems that allow pharmaceutical researchers to rapidly screen drugs and medical compounds thereby accelerating and improving drug discovery.

Tecella offer a range of instruments for this fundamental technique and have recently introduced the Flex and Impulse multiple channel models.

Flex – 8 to 96 channels

The Flex is a multi-channel patch clamp amplifier configurable from 8 to 96 channels in 8 channel steps.

It offers a comprehensive range of standard and customisable features:

Standard features

  • Voltage clamp
  • Low noise integrated digitiser
  • Internal head stage per channel
  • Internal model cell per channel
  • USB interface
  • TecellaLab software
  • USB powered for 16 channels or less

Custom features

  • Whole Cell, Bilayer, or Electrochemistry models
  • Current clamp
  • Command voltage range
  • Command current range
  • Gain values
  • Series resistance compensation range
  • Capacitance compensation

Impulse – 8 to 64 channel MEA amplifier

Impulse is a new compact and low noise 64-channel microelectrode array amplifier designed to work with a variety of probes. A Windows DLL is available for custom development and OEM integration.

For more information, please contact us.


Meet us at Focus on Microscopy 2019 from Sunday

The Focus on Microscopy (FOM2019) conference and exhibition begins this Sunday morning, April 14th, at the QEII Conference Centre in London, and runs for four long days.

FOM is an annual event that takes places in various countries around the world, presenting the latest innovations in optical microscopy and their application in biology, medicine and the material sciences. Topics will cover:

  • 3D optical imaging and image processing
  • Adaptive optics for microscopy
  • Coherent non-linear microscopies
  • Confocal and multiphoton-excitation microscopy
  • Correlated microscopies, light/electron
  • Developments in resolution and imaging
  • Fluorescence image, labelling and spectroscopy
  • Laser manipulation and tracking
  • Light sheet microscopy
  • OCT and holographic endoscopy
  • Phase/interference based microscopies
  • Raman spectroscopy imaging
  • Super-resolution nanoscopy
  • … and more

Elliot Scientific will be on stand 2 at the sold-out exhibition. We will be featuring Accurion active anti-vibration products; ultra-bright LED light sources from Prizmatix; and manipulators, stages and other microscopy accessories by Siskiyou.

Come and chat to us about our Optical Tweezer systems, digital holographic microscopes (DHM) from Lyncée Tec, and WITec confocal Raman imaging microscopes. We also offer Patch Clamp amplifiers manufactured by Tecella and the Kinetic Systems’ passive anti-vibration table and platform range, as well as HOLOEYE SLMs and CRAIC Technologies’ microanalysis systems.

For readers keen on acronyms and abbreviations, here a selection to get your teeth into: FCS, FLIM, FRAP, FRET, GSDIM, PALM, SHG, SIM, SOFI, STED, STORM, THG, and TIRF

 


April 2019 newsletter now online

April 2019 NewsletterThe Elliot Scientific April 2019 Newsletter: In this issue Gamma Scientific introduce a motorised iris for the RS-7 SpectralLED tuneable light source, Lake Shore manage to go low with calibrated Ruthenium Oxide temperature sensors for extreme cryogenic measurements, Siskiyou make mounts movable from above for those tricky optical breadboard set-ups, and we announce that our Applications section packed with useful information for scientists is now live, plus Focus on Microscopy 2019 in Westminster next week.

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March 2019 newsletter now online

March 2019 NewsletterThe Elliot Scientific March newsletter is now available. In this special life science issue we reveal how WITec’s new ParticleScout can help quickly identify and quantify, pollutants, unveil three new videos of products for microscopy and optogenetics from Prizmatix, announce that Siskiyou’s range of motorised manipulators are now available in the UK and Ireland, and show how Digital Holographic Microscopy from Lyncee Tec can help the research scientist, plus Magnetism 2019 in Leeds next month.

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Motorised Siskiyou micromanipulators for bioscience (and microelectronics)

For interaction with a microscope sample, the micromanipulator has been a staple of the biologists toolkit from the beginning of the 20th century.

Used for holding, injecting or cutting, the precision of the micromanipulator’s motion has always been paramount. So many leading researchers, including Dr Robert Chambers and Sir Andrew Huxley, worked on improving the mechanics of these systems over the years.

These early devices relied on adjustment of the individual axes by hand, but by the 1950’s De Fonbrune had developed a pneumatic micromanipulator that allowed all three axes to be operated via a joystick-like controller.

Depending on the application, researchers might need different movement ranges and resolutions, speeds and accuracy; so ranges of micromanipulators are available of different constructions to suit.

Siskiyou Corporation offer mechanical, hydraulic, and electronically-controlled motor adjusted systems.

The latter micromanipulators are fully CE-certified and are now on sale to UK and Irish researchers. Models available include:

MX1641 Series – ideal for introductory level research and training
This crossed roller micromanipulator uses spring-loaded lead screws on three axes to ensure drift-free operation, and a motorised probe axis delivering up to 0.1 µm movement resolution.

MX7600 Series – ideal for patch recording experiments
A fully motorised crossed roller bearing micromanipulator offering exceptionally smooth linear travel via its precision preloaded lead screws to ensure drift-free operation and up to 0.1 µm movement resolution.

MX7800 Series – ideal for multiple patch-recording experiments
This variant of MX7600 series uses a new folded Y-axis stage that narrows the footprint of the manipulator by half. This design enables the mounting of as many as six micromanipulators in a semi­circle from side to side around the front of a microscope.

For more information, please visit our Siskiyou Life Science Products, or contact us.

PS. Micromanipulators can also be useful for holding tools and probes while examining microelectronics under a microscope!

 


Using the most powerful single-chip LEDs available, Prizmatix LEDs are ideal for microscopy and optogenetics research

Prizmatix LEDs for Optogenetics and Fluorescence
  • High-power collimated and fibre-coupled LEDs
  • Wavelengths available from UV to Red
  • White Light and Multiple LED Sources

Prizmatix specialises in LED illumination systems for industrial applications, and science, especially in microscopy and optogenetics research.

The Prizmatix High Power and Ultra-High-Power (UHP) models are built using the most powerful single-chip LEDs available. These versatile illumination solutions offer:

Modularity
The modular systems deliver flexibility with a collimated beam. Fitted with a standard SM1 thread at the port, they can be fitted with a variety of accessories such as a fibre coupler adaptor, beam combiner, filter wheel, and more. The accessories are easy to fit and swap, so different set-ups only take minutes.

High efficiency
The fibre-coupled LED models have a highly efficient coupling that optimises the output such that these systems deliver roughly 1.5x more light when compared to Prizmatix LEDs used with a fibre adaptor. The LED controller is in-built to maximise its compactness.

Wide range of powers
High Power LED models are equipped with a 1 mm² single chip LED and can deliver up to 300 mW of optical power, while the UHP models have a 12 mm² single chip LED punching out up to 5 W of optical power. (As measured after the collimating optics)

Broad range of wavelengths
Choose from dozens of standard LEDs that operate at monochromatic wavelengths between 340 and 940 nm, and ‘white’ light models with a choice of spectral outputs. Deep UV and IR LEDs are also available on request.

Controls
Each of the extremely low-noise LED controllers has TTL and analogue input. In combination with a USB-control box, the LEDs can be controlled from a PC using µManager, LabView, Matlab or directly using HyperTerminal commands. An optional photodiode feedback loop enables the LEDs to be power stabilised.

Accessories
In addition to fibre coupling adaptors, collimators and filter wheels, custom-made fibres and fibre bundles with high numerical apertures of up to 0.63 are available. Optogenetics researchers can also order cannulae, rotary joints, and programmable signal generators for use in their experiments.

For more information, please visit our Prizmatix webpages or contact us.

 


February 2019 newsletter now online

February 2019 NewsletterThe Elliot Scientific February newsletter is now available. In this issue we go in deep with Lyncee Tec’s R-Series of Digital Holographic Microscopes, welcome the return of OptiBlocks from Prizmatix to our webpages, announce a training capability for spectroscopists interested in Raman Imaging from WITec, and recommend fiber optic components manufactured by market leader OZ Optics.

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We would like to say a big thank you…

We would like to say a big thank you to the people who visited our booth at Photonics West 2019 and met with Dr. Adrian Knowles in his new role as Elliot Scientific’s Managing Director. You certainly made it a successful event all round for both him and us.

Many visitors were impressed by our Elliot|Martock compact stage portfolio. These precision engineered dovetail slides are offered in a range of sizes and travels, delivering smooth backlash-free motion in X, XY, XZ, YZ or XYZ directions. Of particular interest to some were the miniature rotation stages.

Our Optical Tweezers demonstration videos are always attention grabbers, and a number of biophysicists and scientists from other disciplines stopped by to discuss how our cost-effective systems could help them in their projects. Researchers working within tight budgets were delighted to hear that Elliot Scientific laser trapping could be added to their existing (expensive) microscope without the need to buy a whole new instrument.

Elliot|Martock Gold Series Flexure Stages also proved of interest to many involved in light, optics and electronics due to their versatility. These world-renowned devices offer superior manipulation in three axes, and with minimal arcuate displacement they enable nanometre positioning for critical applications that include fiber launch and waveguide alignment. A comprehensive range of standard and customisable accessories are available too.

If you didn’t get to see us and our products at Photonics West, please visit our website or contact us for more information.

 

 


Photonics West opens today – Elliot Scientific in Booth 4660

The annual Photonics West group of exhibitions and conferences organised by SPIE – the international society for optics and photonics – opens today and runs till Thursday at San Francisco’s Moscone Center.

Elliot Scientific is exhibiting in Booth 4660 – look out for our banner (right) and new background (below).

 

We will be demonstrating our renowned range of XYZ flexure stages and precision micro- and nano-positioning slides, our fully automated DAli3 alignment system, as well as showing our Optical Tweezers add-on for professional microscopes.

More information can be found out about Photonics West 2019 here


January 2019 newsletter now online

January 2019 NewsletterThe Elliot Scientific January newsletter is now available. In this issue we say hello to Digital Holographic Microscopy specialists Lyncée Tec as we expand our life science range of products that currently come from Accurion, CRAIC Technologies, Elliot Scientific, HOLOEYE, Kinetic Systems, Prizmatix, Siskiyou, Tecella, and WITec. We also look at Lake Shore’s new M91 FastHall controller and remind you of next month’s Photonics West.

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Elliot Scientific now representing Digital Holographic Microscopy company Lyncée Tec SA

Elliot Scientific has signed an exclusive distribution agreement with Lyncée Tec SA, of Lausanne in Switzerland, to distribute and support their range of holographic microscopes based on the revolutionary patented Digital Holographic Microscope (DHM®) technology.

DHM® are 3D optical profilometers characterised by an unrivalled high measurement rate and a very short exposure time. These unique features make possible applications not conceivable using white light interferometers and confocal microscopes: 3D topography measurements in presence of environmental vibration or of intrinsic sample vibration, sample characterization in cryogenic and high temperature environments, large area screening, and analysis of the deformation dynamics of samples due to external stimuli such as temperature and pressure changes, light irradiance, mechanical force, or electromagnetic fields.

In life sciences, DHM® enables label-free non-invasive millisecond to multi-days continuous measurement of cells. Quantitative phase measurements provide quantitative information about cell morphology and intracellular content, cell proliferation and viability, trans-membrane ionic currents and water transport among others.

“We are excited to work with Elliot Scientific, an innovative company with a highly qualified staff that will provide the highest levels of service and knowledge. DHM® are complementary to Elliot’s product line.” said Dr. Yves Emery, CEO of Lyncée Tec. “This agreement enables us to provide high quality products, services, as well as scientific and technological support.”

More information can be found on the Elliot Scientific website at www.elliotscientific.com/Lyncee-Tec-Digital-Holographic-Microscopes

About Lyncée Tec SA

Founded in 2003, Lyncée Tec SA is the leading company in the field of Digital Holography Microscopy (DHM®). The company offers directly and through distribution and OEM partners a broad range of products covering sample holders and conditioning accessories, stand alone and camera-like DHM®, and software modules for efficient analysis of measurement data. Systems have been designed specifically both for R&D and for quality inspection. They are used in the fields of micro production, industrial metrology, MEMS, semi-conductor, micro-optics, watch industry, and cell imaging. For more information, please visit www.lynceetec.com


Elliot Scientific’s 2018 newsletters published in one volume

Elliot Scientific’s renowned monthly newsletters have been compiled into a single edition for the year 2018.

The 32-page volume can be:

Read online via Issuu

Downloaded from our website

or viewed by clicking here


December 2018 newsletter now online

December 2018 NewsletterThe Elliot Scientific December newsletter is now available. In this issue we start offering WITec confocal Raman imaging solutions within the UK and Ireland, Mad City Labs say Nano-ZL is ideal for high-speed multiwell plate imaging, Rugged Monitoring introduce multi-channel capability with new T301 module, and Seebeck coefficient measurement is explained in a video from DEMCON|kryoz, plus our winter holiday schedule.

To view it in a browser, click here.

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Elliot Scientific now representing Raman Imaging specialists WITec in the UK and Eire

Unique correlative analysis in one instrument: Raman/AFM, Raman/SNOM

Elliot Scientific has signed an exclusive distribution agreement with WITec GmbH, of Ulm in Germany, to distribute their range of award-winning Raman imaging instruments.

WITec is a market leading manufacturer of high-quality micro- and nano-analytical imaging equipment featuring confocal Raman microscopy, Atomic Force Microscopy (AFM) and Scanning Near-field Optical Microscopy (SNOM) techniques for the geoscience researcher, forensic scientist, pharmaceutical lab technician, semiconductor manufacturer, and food and drinks technologist.

The WITec product line of high-resolution SNOM, AFM and confocal Raman imaging solutions will be the responsibility of our Managing Director, Dr. Adrian Knowles.

Adrian is a qualified chemist and is well known within the spectroscopy community, especially within the field of Raman spectroscopy. His knowledge encompasses a wide range of technologies that include CCD cameras, fibre-optics, microscopy systems, Raman spectrometers and fluorimeters. His broad market visibility has been fundamental in the success and growth of several photonics and spectroscopy companies during his 20 year career.

Our team of scientists and engineers has nearly 30 years of experience in sales of light-based technologies to academia and industry. With expertise in key WITec application areas of forensics, geoscience, the life sciences, materials science, photonics and semiconductors, Elliot Scientific is the ideal partner for supporting WITec instruments within the UK and Ireland.

More information can be found on our website at www.elliotscientific.com/Raman-Imaging


New High Brightness White Light Fibre Coupled Light Source from Prizmatix

The HB-FC-White high-brightness fibre-coupled light sources from Prizmatix are designed especially for OEM illumination applications in life science instrumentation, machine vision.

The HB-FC-White is a self-contained light source that includes all the necessary driver electronics and a thermal management system – no special controller box is required to operate the unit if used at the preset power.

  • Single chip long-life LED
  • High brightness cool-white light
  • High power from a small core fibre
  • Isolated TTL and analogue input
  • Optional fast TTL switching (200 ns)
  • Low optical noise
  • Optional remote control
  • Optional USB or RS-232 control
  • For OEMS:
    • Simple integration
    • I²C remote control protocol

Typical optical power from distal end of 1 m fibre:

Fibre Type Fibre Core Fibre NA Output Power
Polymer 1000 µm 0.63 460 mW
Polymer 500 µm 0.63 245 mW
Glass 250 µm 0.66 110 mW
Silica 50 µm 0.2 0.5 mW

For more information, please contact us.